Diagnoses and Treatments for Various Types of Systemic Vasculitis

Kawasaki Disease

 

Each of the diseases listed directly below in this section will have 2 sections: Diagnostic Work-up and Treatment Protocols. An example of this set-up is shown below under “Kawasaki disease”.

  • Kawasaki disease (Example)
  • Diagnosis of Kawasaki disease (Classification, Clinical, Lab, Imaging, Diagnostic Images, Diagnostic Algorithm etc.)

Diagnostic images (mentioned above) will include images of symptoms associated with each respective disease. For example:  Image 3 displays an image of conjunctivitis in Kawasaki.

  • Treatment of Kawasaki disease
    • Childhood polyarteritisnodosa
      • Diagnosis
      • Treatment
    • Cutaneous polyarteritisnodosa
      • Diagnosis
      • Treatment

Takayasu Arteritis

Classification:

  • According to the 2010 European League Against Rheumatism (EULAR)/ Pediatric Rheumatology International Trials Organization (PRINTO) and Pediatric Rheumatology European Society (PRES) criteria for classification of TA, a patient must present with angiographic abnormalities plus have a minimum of 1 of the following features:
  1. Decreased peripheral artery pulse(s) or claudication of extremities
  2. Blood pressure difference >10 mmHg in systolic blood pressure between arms.
  3. Bruits over the aorta or its major branches
  4. Hypertension
  5. Acute phase reactant (Erythrocyte sedimentation rate >20mm per first hour or CRP any value above normal)
  • In order to reach a diagnosis, it is important to consider a combination of clinical features, specific raised inflammatory markers, along with specific imaging patterns. For more details view the diagnostic algorithm for Takayasu arteritis.

Clinical features:

  • 10% of patients do not show symptoms. These patients do, however, show abnormal vascular patterns when examined.
  • The patients that do present with symptoms will likely experience some of the following:
Non-specific systemic symptoms: Specific Symptoms:

 

Neurological Symptoms:
Fatigue

Fever

Arthralgia (pain in joint)

Weakness

Myalgia (muscle pain)

Night sweats

Weight loss

Malaise

Shortness of breath

Symptoms secondary to ischemia of organs

Claudication (cramping in arms or legs)

Hypertension (high blood pressure), often renal hypertension

Lower blood pressure and weaker pulse in upper limbs

Coldness or numbness of fingers

Discrepancy in blood pressure between arms

Headache

Vision changes

Stroke

Transient ischemic attack

 

 

Each of the diseases listed directly below in this section will have 2 sections: Diagnostic Work-up and Treatment Protocols. An example of this set-up is shown below under “Kawasaki disease”.

  • Kawasaki disease (Example)
  • Diagnosis of Kawasaki disease (Classification, Clinical, Lab, Imaging, Diagnostic Images, Diagnostic Algorithm etc.)

Diagnostic images (mentioned above) will include images of symptoms associated with each respective disease. For example:  Image 3 displays an image of conjunctivitis in Kawasaki.

  • Treatment of Kawasaki disease
    • Childhood polyarteritisnodosa
      • Diagnosis
      • Treatment
    • Cutaneous polyarteritisnodosa
      • Diagnosis
      • Treatment
    • Takayasu arteritis
      • Diagnosis: Please insert the diagnosis info found in the “Takayasu Arteritis – outline and content” document.
      • Treatment: Please insert the treatment info found in the “Takayasu Arteritis – outline and content” document.
    • Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
      • Diagnosis
      • Treatment
    • Granulomatosis with polyangiitis (Wegener’s)
      • Diagnosis
      • Treatment
    • Microscopic polyangiitis
      • Diagnosis
      • Treatment
    • Henoch-Schönlein purpura (IgA vasculitis)
      • Diagnosis
      • Treatment
    • Isolated cutaneous leukocytoclastic vasculitis
      • Diagnosis
      • Treatment
    • Hypocomplementemic urticarial vasculitis
      • Diagnosis
      • Treatment
    • Behçet’s syndrome
      • Diagnosis
      • Treatment
    • Secondary vasculitides due to infection, malignancy, or drugs, including hypersensitivity vasculitis
    • Isolated vasculitis of the central nervous system
    • Cogan’s syndrome
    • Unclassified
    • Diagnostic Images Collection

This section serves as a general collection of all the available diagnostic images